The study of gene regulatory networks (GRNs) is fundamental to the understanding of evolutionary dynamics and artificial life modeling. This paper presents an integration of a GRN into the NK-fitness landscape model and explores the impact of sparsity on epistasis and pleiotropy. As sparsity augments, gene interactions diminish, expectedly leading to a reduction in both epistasis and pleiotropy. Our findings corroborate the model’s response to such perturbations, demonstrating its potential for investigating a range of GRN adaptations within the NK-fitness landscape framework.

Issue Section:
General Conference
epistasis, pleiotropy, gene regulatory network, evolution
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© 2023 Massachusetts Institute of Technology Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license
2023
Massachusetts Institute of Technology
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Issue Section:
General Conference