ALife is primed to address the biggest challenges in astrobiology by simulating systems which capture the most general and fundamental features of living systems. One such challenge is how to detect life outside of the solar system— especially without making strong assumptions about how life would manifest and interact with its planetary environment. Here we explore an ALife model meant to overcome this problem, by focusing on what life may do, rather than what life may be: life can spread between planetary systems (panspermia) and can modify planetary characteristics (terraformation). Our model shows that as life propagates across the galaxy, correlations emerge between planetary characteristics and location, and these correlations can function as a biosignature. This biosignature is agnostic because it is independent of strong assumptions about any particular instantiation of life or planetary characteristic. We demonstrate (and evaluate) a way to prioritize specific planets for further observation—based on their potential for containing life. We consider obstacles that must be overcome to practically implement our approach, including identifying specific ways in which better understanding astrophysical and planetary processes would improve our ability to detect life.

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